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Gene expression changes induced by Atorvastatin in breast cancer and stem cells

Authors :

Seyed Mahdi Mousavi¹ Yaghub Pazhang²

1- دانشگاه ارومیه 2- دانشگاه ارومیه

Keywords :

Atorvastatin،Bioinformatic،Cholesterol Metabolism،Gene Expression،Breast Cancer Cell line& Induced Pluripotent Stem Cells

Abstract :

This research focuses on how atorvastatin influences gene expression in breast cancer cell lines (MCF-7, MDA231, BT474, and SKBR3) and human pluripotent stem cells (iPSCs), using bioinformatics data from the GEO database. The results showed that atorvastatin significantly enhances the expression of key cholesterol metabolism-related genes, such as SQLE, ACAT2, HMGCS1, NSDHL, HMGCR, and DHCR7. Although atorvastatin is widely recognized for its cholesterol-lowering properties and cardiovascular benefits, our findings indicate it may also play a dual role by promoting the proliferation and migration of cancer cells through the upregulation of these genes. To further investigate the biological interactions among the differentially expressed genes, a protein–protein interaction (PPI) network was constructed using the STRING database. The analysis revealed strong interactions among cholesterol biosynthesis proteins, especially HMGCR and DHCR7, which have been associated with heightened growth and migration abilities in gastric and breast cancer cells. These observations raise concerns about atorvastatin's potential carcinogenic effects, highlighting the need for more comprehensive studies to better understand its impact on these genes and its role in cancer development.