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Synthesis and Characterization of an Injectable Magnetic Scaffold Based on Alginate/Chitosan and Zero-Valent Iron for Hyperthermia

Authors :

Mohammad Jafari Fashtami¹ Bahareh Khalilivavdareh² Delaram Dezfoulian³ Maryam Tajabadi⁴

1- دانشگاه علم و صنعت ایران 2- دانشگاه علم و صنعت ایران 3- دانشگاه علم وصنعت ایران 4- دانشگاه علم و صنعت ایران

Keywords :

Magnetic hydrogel،Injectable scaffold،Alginate،Chitosan،Zero-valent Iron Nanoparticle (nZVI)،Hyperthermia

Abstract :

In this study, we propose an innovative approach for targeted hyperthermia therapy by developing injectable magnetic scaffolds based on alginate/chitosan (CS) composites integrated with zero-valent iron nanoparticles (nZVI), which has not been systematically investigated before. Alginate and CS, both biocompatible and biodegradable materials, were used to create a stable, injectable hydrogel matrix. This study focuses on the synthesis and characterization of a magnetic hydrogel intended for cancer treatment. nZVI nanoparticles were incorporated to enhance the magnetic properties, facilitating targeted heat generation under an external magnetic field. The synthesized hydrogels were characterized through various techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX), which confirmed the successful integration of nZVI and the hydrogel matrix. The hydrogel exhibited desirable properties such as high swelling ratios, good stability, and effective degradation profiles, making it suitable for magnetic hyperthermia applications.