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Perfluorocarbon-Based Oxygenation Systems: From Foundational Principles to Revolutionary Applications in Cancer Therapy and Tissue Engineering

Authors :

Gity Mirzaei¹ Zeinab Mazloumi² Ali Baradar Khoshfetrat³

1- دانشگاه صنعتی سهند 2- دانشگاه علوم پزشکی تبریز 3- دانشگاه صنعتی سهند

Keywords :

Perfluorocarbons،Oxygenation،Tissue Engineering،Cancer Therapy

Abstract :

Overcoming oxygen diffusion limitations is critical in tissue engineering and oncology. This review examines perfluorocarbons (PFCs), synthetic compounds with exceptional oxygen solubility, as versatile solutions for oxygen delivery. PFCs' fundamental properties, mechanisms of oxygen transport, and their evolution from blood substitutes to advanced nanoplatforms were explored. Key applications include sustaining cell viability in engineered tissues and enhancing cancer therapies by reversing tumor hypoxia. PFCs improve radiotherapy efficacy, drug delivery, and immunotherapy response by oxygenating tumors and promoting immune cell infiltration. Also, clinical translation challenges, highlighting PFCs' potential to revolutionize therapeutic outcomes across biomedical fields were addressed.