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سی و دومین کنفرانس ملی و دهمین کنفرانس بین المللی مهندسی زیست پزشکی ایران
FSI Modeling of Osteocyte Mechanotransduction Under Dynamic Loading
Authors :
Zahra Rahmanisamani
1
Hanieh Niroomand-Oscuii
2
Mohammad Niroobakhsh
3
Ehsan Alizad Farokhi
4
1- دانشگاه صنعتی سهند تبریز
2- دانشگاه صنعتی سهند تبریز
3- Purdue University
4- دانشگاه صنعتی سهند
Keywords :
Fluid–structure interaction،osteocyte،lacunar–canalicular network،fluid flow shear stress،finite element analysis،dynamic loading
Abstract :
Osteocytes, the principal mechanosensors of bone, detect loading primarily through fluid flow shear stress in the lacunar–canalicular network. In this study, an idealized three-dimensional finite element fluid–structure interaction model was developed to investigate, for the first time, the combined effects of loading type and strain magnitude. Dynamic gait-like input was compared with static compression, and peak strains of 3000 and 3500 microstrain were applied. Dynamic loading induced stronger interstitial fluid transport, with more than 50 percent of dendrites experiencing shear stress above the osteogenic threshold, compared with only 33 percent under static loading. This effect was accompanied by higher mean pressure gradients, confirming the role of oscillatory input in broadening dendritic stimulation. Increasing strain magnitude enhanced osteocyte deformation, tissue stress, and energy storage, while fluid responses showed only modest rises in mean pressure and shear stress. These findings demonstrate that dynamic loading provides a more effective stimulus for osteogenic signaling than static compression, whereas elevated strain magnitudes near the upper physiological range may increase the likelihood of microdamage.
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