سامانه همایش‌ها TSTA | ثبت‌نام و ارسال مقاله کنفرانس‌ها و کنگره‌های ملی

صفحه اصلی / سی و دومین کنفرانس ملی و دهمین کنفرانس بین المللی مهندسی زیست پزشکی ایران

Structural Insights into the Molecular Mechanism of Cancer Regulator BRCA1 Methylation

نویسندگان :

Shadi Asadi¹ Maryam Azimzadeh Irani²

1- Shahid Beheshti University 2- Faculty of Life Sciences and Biotechnology Shahid Beheshti University

کلمات کلیدی :

DNA methylation،tumor suppressor gene،BRCA1،structural analysis،promoter methylation

چکیده :

Hypermethylation of the BRCA1 promoter may induce structural alterations that impact gene regulation. This study employed AlphaFold-based structural modeling to examine how methylation affects key DNA conformational parameters. Our findings provide computational insights into how hypermethylation influences the structural features of DNA and interferes with gene expression.