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صفحه اصلی / سی و دومین کنفرانس ملی و دهمین کنفرانس بین المللی مهندسی زیست پزشکی ایران

Evaluation of Mechanical and Biological Properties of PCL-coated Magnesium Scaffolds

نویسندگان :

Fatemeh Sharifabadi¹ Sayed Khatiboleslam Sadrnezhaad²

1- دانشگاه صنعتی شریف 2- دانشگاه صنعتی شریف

کلمات کلیدی :

Porous magnesium scaffold،Polycaprolactone (PCL)،Compressive strength،Biodegradability

چکیده :

Abstract— Magnesium scaffolds, owing to their mechanical properties similar to natural bone and their biodegradability, are considered promising candidates for tissue engineering applications. In this study, Mg–Zn–Ca scaffolds were fabricated using the powder metallurgy method with different porosity agents (10% and 30% urea) and subjected to compression testing. The results showed that the 10% urea samples exhibited higher compressive strength (~105 MPa) compared to the 30% urea samples (~68 MPa), while higher porosity provided more favorable conditions for tissue ingrowth. To enhance the mechanical and biological performance, polycaprolactone (PCL) coating was applied to the scaffolds. Findings revealed that a single-layer PCL coating increased compressive strength by approximately 10–20%, while a three-layer coating led to an improvement of about 20–30% compared with uncoated samples. Moreover, the PCL coating acted as a protective barrier, reducing the degradation rate and providing more favorable biocompatible conditions. Overall, the results indicate that the application of PCL coating is an effective approach to improve both mechanical stability and biological performance of magnesium scaffolds for bone regeneration applications.