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صفحه اصلی / سی و دومین کنفرانس ملی و دهمین کنفرانس بین المللی مهندسی زیست پزشکی ایران

DMAEMA-based photocrosslinkable hydrogels with injectable capabilities for smart drug delivery systems in implant infections

نویسندگان :

Fatemeh Haj Sadeghi¹ Vahid Haddadi Asl² Hanie Ahmadi³

1- دانشگاه صنعتی امیرکبیر(پلی تکنیک تهران) 2- دانشگاه صنعتی امیرکبیر(پلی تکنیک تهران) 3- دانشگاه صنعتی امیرکبیر(پلی تکنیک تهران)

کلمات کلیدی :

Injectable materials،Smart drug delivery hydrogel،Implant infection،photo crosslinking

چکیده :

A novel class of photocrosslinkable hydrogels with precisely tunable properties was developed for advanced biomedical applications. Using RAFT polymerization, we synthesized two distinct block copolymers, PDMAEMA-b-PMMA-CM, with varying coumarin contents (LCP and HCP). Our structural characterization confirmed the successful incorporation of all monomer units and validated that the HCP polymer contains a significantly higher coumarin content (8.6%) than the LCP sample (4.8%). We systematically investigated the effect of this compositional difference on material performance. Rheological analysis demonstrated that both hydrogels exhibit critical shear-thinning behavior, a key property for minimally invasive injection. Furthermore, the higher coumarin content in HCP led to a superior photodimerization efficiency and a more robust network with enhanced mechanical properties. Ultimately, the hydrogels proved to be a versatile and smart drug delivery platform, allowing for controlled release governed by the network's crosslinking density and a rapid, triggered release in response to acidic environments. This study establishes a clear structure-property relationship, confirming the potential of these injectable materials for targeted therapeutic delivery in applications such as implant-related infection control.